About This Document =================== SilcsBio offers a suite of computer-aided drug design software including: * the patented SILCS functional group mapping approach with capabilities for (a) small-molecule database screening, fragment-based drug design, and lead optimization, and (b) excipient screening for biomacromolecular therapeutics; * the SSFEP method that delivers free energy calculations 1,000 times faster than standard FEP; and * the CGenFF force field parameter assignment engine. This documentation covers how to install and use the software.