About This Document

SilcsBio offers a suite of computer-aided drug design software including:

• the patented SILCS functional group mapping approach with capabilities for

  1. small-molecule database screening, fragment-based drug design, and lead optimization, and

  2. excipient screening for biomacromolecular therapeutics;

• the SSFEP method that delivers free energy calculations 1,000 times faster than standard FEP; and

• the CGenFF force field parameter assignment engine.

This documentation covers how to install and use the software.